Beilstein J. Org. Chem.2017,13, 1486–1497, doi:10.3762/bjoc.13.147
systems within a synthetic chemical framework. Living systems rely on complex networks of chemical reactions to control the concentration of molecules in space and time. Despite the enormous complexity in biological networks, it is possible to identify networkmotifs that lead to functional outputs such
chemical entities on the properties of the network as a whole. Ultimately, this approach should allow us to not only understand such complex networks but also to guide and control their behavior.
Keywords: chemical reaction network; complexity; dissipative systems; networkmotifs; out-of-equilibrium
accurate modelling and has revealed fundamental features that would otherwise be too difficult to comprehend [24]. It is generally accepted that complex molecular networks, like electrical circuits, are constructed from simpler modules (networkmotifs) and control the regulatory functions as well as the
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Graphical Abstract
Figure 1:
Network motifs. (a) Examples of network motifs composed from different feedback loops. Each design ...